How much bigger the number of hidroxilas in the one structure flavonide, greater is its antirust activity. This is a factor that can be explored in the elaboration of a new frmaco (JOHANN, 2003). Flavonides blocks the chains of oxidativas reactions, when donating a H+ ion to the free radical, forming a steady radical (LUZIA; JORGE, 2009). With the reduction of these harmful agents, the organism does not develop degenerative illnesses as the peptic ulcer (RODRIGUES et al., 2008). Beyond flavonides, the fruits of the Citrus sort spp. they present in its essential oil metablitos, as the Limoneno, – pinemo (ROZZA, 2009) and – mirceno that they act of different forms in gastroproteo (BONAMIN, 2010). 2. OBJECTIVE 2.1.
General objectives Through revision of literature, the present objective study the vegetal composite use with therapeutical potential for the treatment of peptic ulcer. 2.2. Specific objectives To demonstrate new a therapeutical one for the peptic ulcer, through the job of fruits of the Ctrus sort spp. that it presents constituent with powerful antiulcerognica activity. 3. DEVELOPMENT 3.1.
Gastric acid secretion mechanisms the stomach is coated by composed the gastric mucosa, antrais fabric for oxnticas glands and glands. The oxnticas glands are formed by parietais cells (secretoras of acid clordrico), main cells D (secretoras of somatostatina), cells enterocromafins (ECF) (secretoras of histamina) and cells (secretoras of pepsinognio). The antrais glands are constituted of the same cellular type of the oxnticas glands, except the parietais cells (RODRIGUES, 2008). The secretions of the epithelial, parietais and main cells mucous, form the gastric juice. Cells G secretam in the sanguineous chain the gastrina hormone. The gastrina relaxes the pilrico sphincter, increases the gastintestinal motilidade and stimulates the secretion of acid clordrico (TORTORA, 2000). The parietais cells secretam acid clordrico through nervous and hormonais mechanisms. Stimulatons as vision, palate, olfato and the distenso of the musculatura of the stomach for the food presence, stimulate the release of acetilcolina (Ach) for the vacant nerve in the fabric gastric (BLACKSMITH, 2005).